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Reference 1:
Safety Data Sheet for Chemical Substances and Other Materials (Example)

Company: XXX Chemical Industries, Inc.
Address: XX Kasumigaseki, Chiyoda-ku, Tokyo
Dept. and person in charge: Environmental Safety Dept., Ichiro Yamasa
Phone: 0000-0000 Fax: 0000-0000
Emergency contact: XX Plant, XXX Chemical Industries, Inc.
Phone: 0000-0000
 

 Created April 1, 1996
 

 Name

Ethyl acetate
 

Properties 

Chemical name 

 Ethyl acetate 

Content 

 99% or more 

Structural formula 

 CH3COOC2H5 

Official governmental reference number 

 (2)-726 
(Law Concerning the Examination and Regulation of Manufacture, etc., of Chemical Substances) 

CAS number 

 141-78-6 
United Nations classification 3.2 (medium flash point flammable liquid) 
United Nations Number 1173 

Hazards/Toxicity 

 Type:

 Acute toxicity and flammability 

 Toxicity:

 Vapors irritate the eyes, nose, and throat. Inhalation causes an anesthetic effect. 

Emergency Measures
 Eye contact: Immediately rinse eye(s) under running water for 15 minutes or more, and then seek medical attention. 
 Skin contact: Take off contaminated clothing, and then rinse the affected site with a large quantity of water. Seek medical attention for any skin inflammation. 
 Inhalation: Immediately move affected people to an area of fresh air, keep them still and warm, and seek medical attention as soon as possible. Perform CPR if breathing stops. 
Ingestion: Seek immediate medical attention. If the affected person is unconscious, do not attempt to administer anything orally or induce vomiting. 
 

Fire-Fighting Measures 

Method: 

 Cut off the fuel source from the fire, and then put out with an extinguishing agent. To ensure that the fire does not spread, spray water on surrounding tanks and the building to cool them down. Fight the fire from an upwind position, and use a respirator when necessary. 

Extinguishing agent: 

 Water, powder, carbon dioxide, and alcohol foam are all effective. 

Leakage Measures 
  • Remove anyone downwind of the leak. Cordon off the leakage site with a rope or other means to prevent anyone from entering. Promptly remove any ignition sources nearby. Always wear protective equipment during cleanup work. Do not perform cleanup work downwind of the leak. 
  • If only a small amount leaked, soak it up with dirt, sand, or other such materials, collect it into an empty container, and then rinse with a large quantity of water. 
  • For major leaks, stop the flow with dirt, sand, or other such materials. After guiding the flow into a safe location, cover the surface of the liquid with foam or other such agent, and then collect as much as possible into empty containers. Finally, rinse with a large quantity of water, making sure that the concentrated liquid does not get into rivers or other bodies of water. 

Precautions on Handling and Storage 

Handling: 
  • Use appropriate protective equipment to ensure that the chemical is not inhaled and does not come in contact with the eyes, skin, or clothing. Work upwind from the chemical whenever possible. 
  • Tightly seal containers or install a local exhaust system. 
  • Avoid objects with high temperatures, sparks, and flames. Avoid contact with strong oxidizing agents. 
  • Take anti-static measures, and use work clothes and work boots that are conductive. 
  • Do not handle in a manner in which containers will fall over, drop, be exposed to impacts, or dragged along a surface. 
  • Once the chemical is used up, collect empty containers at a single location. 

Storage: 
  • Make sure all electrical equipment used in the storage area is of explosion-proof construction, and make sure all equipment is grounded. 
  • Do not place containers in direct sunlight. Store in cool, dark location. 
  • Do not place near combustible material or heat sources such as boilers. 
  • Do not place in the same location as oxidizing substances or organic peroxides. 

Measures for Preventing Exposure 
Controlled concentration:  400ppm 
Permissible concentration: 
Japanese Association of Industrial Health recommended value (1995):  400ppm 
ACGIH (TLV) (1995-96):  TWA 400ppm 
OSHA (PEL) (1995):  400ppm 
Facility measures: 
  • When using in indoor workplaces, seal the source or install a local exhaust system. 
  • Install a safety shower and a place to wash hands and eyes near location where chemical will be handled. Make the location of these clear to all. 
Protective equipment:  Depending on the situation, use organic gas mask, air masks, respirators, protective goggles, protective gloves, and protective boots. 

Physical/Chemical Properties 

Appearance: 

 Colorless liquid 

Odor: 

 Sweet smell 

Specific gravity: 

 0.902

Boiling point: 

 77°C 

Melting point: 

 -84°C 

Vapor pressure: 

 100mHg
(27°C) 

Solubility in water: 

 7.9g/100ml 

Organic solvent:  

 Readily soluble

Fire/Explosion Hazard Data 

Flash point: 

 -4°C 

Ignition point: 

 427°C 
(Stability and reactivity) Explosive range from 2.2 to 11.0 vol.% 
Vapors are heavier than air and tend to collect low to the ground, sometime generating an explosive mixture with the potential of igniting from a long distance. 

Health Hazard Data  

Acute toxicity:

Ingestion:

Rat LD

5,620mg/kg

Mouse LD

4,100mg/kg

Inhalation:

Rat LC

1,600ppm/8H

Mouse LC

31mg/m³

Irritation:

Short time exposure to 400ppm irritates the human eyes, nose, and throat.

Sensitization:

Inflammation of the mucous membrane and eczematous rash after sensitization by ethyl acetate is rare.

Mutagenesis:

Negative in mutagenesis tests using bacteria (conforms to the Industrial Safety and Health Law) 

Subchronic toxicity:

Rabbits exposed for 60 minutes a day to 16 mg/l (about 4,500ppm) of ethyl acetate developed secondary anemia, increased leukocyte counts, visceral edema, and fatty degeneration.

There is also a report stating that there were no abnormal signs or symptoms in employees exposed to 375 - 1,500ppm of ethyl acetate for several months.

Environment Impact Data
Toxicity to fish: Carp  48 hours TLm  40ppm or more 
Water fleas  48 hours TLm 40ppm or more 
Distribution coefficient:  Log Pow = 0.730 

Precautions when Transporting 
  • The sender should give special instructions on shipping to the shipper when transporting the chemical by vehicle or other means. 
  • During transport, care must be taken so that containers do not leak, fall over, drop, or otherwise become damaged. 
  • All relevant laws including the Fire Service Law and Substances Control Law must be obeyed. 

Precautions when Disposing
  • Dispose of by incineration. Employ any of the following methods: 
  • Spray chemical into the incinerator fire chamber and incinerate it. 
  • When there is only a small quantity, soak up with silious earth or similar material, and then incinerate using an open incinerator. 
  • Wastewater containing this chemical should be purified by activated sludge or another process, and then disposed. 

Applicable Laws

Industrial Safety and Health Law Harmful and flammable material requiring clear indication of its name and other important information/ Organic Law: Type II organic solution, etc. 

Fire Service Law: Hazardous material type 4, type 1 petroleum product (non-soluble liquid) 

Substances Control Law: Irritant 

Regulations for the Carriage and Storage of Dangerous Goods in Ships: Flammable liquid and medium flash point flammable liquid

Other Cited Documentation (Reference is omitted here.) 

Contact for Mentioned Material Phone: 0000-0000

 
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