Ordinance on Prevention of Hazards Due to Specified Chemical Substances

Ministry of Labour Ordinance No. 39 of September 30, 1972

Attached Table 4 (related to Article 39)

Type of work	Items
(1) Work to manufacture or handle the substances given below.1) Benzidine or its salts 2) β-naphthylamine and its salts. 3) α-naphthylamine and its salts. 4) P-dimethylaminoazobenzene. 5) Chemicals and other substances which contain substances listed in items 1) to 4) of more than 1% by weight.	1. Investigation into working conditions.2. Cystoscopy or pyelography, when found necessary by medical doctors.
(2) Work to manufacture or handle the substances given below.1) Dichlorobenzidine or its salts. 2) O-tolidine and its salts. 3) Dianisidine and its salts. 4) Magenta. 5) Chemicals and other substances which contain substances listed in items 1) to 4) of more than 1% by weight.	1. Investigation into working conditions.2. Cystoscopy, when found necessary by medical doctors.
(3) Work to manufacture or handle bis (chloromethyl) ether (inclusive of chemicals and other substances which contain bis (chloromethyl) ether of more than 1% by weight.	1. Investigation into working conditions.2. Examination of chest with specified roentgenography, cytological examination on sputum or bronchoscopy when found necessary by medical doctors.
(4) Work to manufacture or handle chlorinated biphenyl, etc.	1. Investigation into working conditions.2. Blood testing of erythrocytic system such as total specific gravity, blood count of red blood cells, etc.3. Testing for blood count of white blood cells.4. Hepatic functional examination.
(5) Work to manufacture or handle beryllium, etc.	1. Investigation into working conditions.2. Chest physical examination.3. Pulmonary ventilation function examination.4. Pulmonary functional diffusion examination, ECC, measurement of urinary or blood beryllium levels, dermatological patching test, or measurement of hematocrit values, when found necessary by medical doctors.
(5-2) Work to manufacture or handle benzotrichloride (inclusive of chemicals and other substances which contain benzotrichloride of more than 0.5% by weight.)	1. Investigation into working conditions.2. Examination of chest with specified roentgenography, cytological examination on sputum, bronchoscopy, examination with cerebral roentgenography, etc., blood testing (inclusive of blood clinical pictures), histopathological examination of lymphatic gland or dermatological histopathological examination, when found necessary by medical doctors.
(6) Work to manufacture or handle acrylamide (inclusive of chemicals and other substances which contain acrylamide of more than 1% by weight.)	1. Investigation into working conditions.2. Medical and neurological examination of peripheral nerves.
(7) Work to manufacture or handle acrylonitrile (inclusive of chemicals and other substances which contain acrylonitrile of more than 1% by weight.)	1. Investigation into working conditions.2. Measurement of plasma cholinesterase action values.3. Hepatic functional examination.
(8) Work to manufacture or handle alkyl mercury compounds (inclusive of chemicals and other substances which contain alkyl mercury compounds of more than 1% by weight.)	1. Investigation into working conditions.2. Measurement of blood and urinary mercury levels.3. Examination for presence of stenosis of visual fields.4. Checking hearing.5. Medical neurological examination of abnormal senses, Rombergsign, inability to do repeatedly antagonistic motions, etc.6. EMG and EEG when found necessary by medical doctors in a case in which abnormal neurological findings are noted.
(9) Work to manufacture or handle asbestos, etc.	1. Investigation into working conditions.2. When the results of direct examination of chest with roentgenography show abnormal shadows (exclusive of fibrous growth change), examination of chest with specific roentgenography, cytological examination on sputum, and bronchoscopy, when found necessary by medical doctors.
(10) Work to manufacture or handle ethyleneimine (inclusive of chemicals and other substances which contain ethyleneimine of more than 1% by weight.)	1. Investigation into working conditions.2. Counting of bone marrow cells.3. Examination of chest with direct or specific roentgenography, cytological examination, bronchoscopy or renal functional examination, when found necessary by medical doctors.
(11) Work to manufacture or handle vinyl chloride (inclusive of chemical and other substances which contain vinyl chloride of more than 1% by weight.)	1. Investigation into working conditions.2. Testing for platelet counts, gamma gultamiltraspepitase (?A-GTP) and Kunkel's reactions (ZTT) when hepatomegaly or splenomegaly are noted.3. Examination with dianogreen method (ICG), testing for lactate dehydrogenase (LDH), testing for serum lipid levels, etc., examination with specific roentgenography, examination of liver or spleen with scintigram, and medical neurological examination of central nervous systems, when found necessary by medial doctors.
(12) Work to manufacture or handle chlorine (inclusive of chemicals and other substances which contain chlorine of more than 1% by weight.)	1. Investigation into working conditions.2. Chest physical examination or examination of chest with direct roentgenography.3. Pulmonary ventilation function examination when objective or subjective symptoms are noted in respiratory organs.
(13) Work to manufacture or handle auramine (inclusive of the chemicals and other substances which contain auramine of more than 1% by weight.)	1. Investigation into working conditions.2. Cystoscopy or hepatic functional examination, when found necessary by medical doctors.
(14) Work to manufacture or handle O-phthalodinitrile (inclusive of chemicals and other substances which contain O-phthalodinitrile of more than 1% by weight.)	1. Investigation into working conditions.2. Blood testing of erythrocytic system covering total specific gravity, blood count of red blood cells, etc.3. EEG when abnormal findings such as epilepsy-like attack are noted in cerebral nervous systems.4. Hepatic functional tests or measurement of urinary phthalic acid levels when gastrointestinal symptoms are noted and when found necessary by medical doctors.
(15) Work to manufacture or handle cadmium or its compounds (inclusive of chemicals and other substances which contain cadmium of more than 1% by weight.)	1. Investigation into working conditions.2. Measurement of urinary cadmium levels.3. Chest physical examination and pulmonary ventilation function examination when objective or subjective symptoms are noted in respiratory organs.4. Urine sedimentation tests, measurement of urinary protein levels, and renal functional examinations when urinary protein is noted.
(16) Work to manufacture or handle chromic acid, etc.	1. Investigation into working conditions.2. Examination of chest with direct or specific roentgenography, cytological examination on sputum, bronchoscopy or dermatological pathological examination, when found necessary by medical doctors.
(17) Work to manufacture or handle chloromethylmethlyether (inclusive of chemicals and substances which contain chloromethylmethylether of more than 1% by weight.)	1. Investigation into working conditions.2. Examination of chest with direct or specific roentgenography, cytological examination on sputum, or bronchoscopy, when found necessary by medical doctors.
(18) Work to manufacture or handle vanadium pentoxide (inclusive of chemicals and other substances which contain vanadium pentoxide of more than 1% by weight.)	1. Investigation into working conditions.2. Examination of sight.3. Chest physical examination or examination of chest with direct roentgenography.4. Examination of pulmonary ventilation functions, measurement of serum cholesterol or triglyceride, or measurement of urinary vanadium, when found necessary by medical doctors.
(19) Work to manufacture or handle coal tar (inclusive of chemicals and other substances which contain coal tar of more than 5% by weight.)	1. Investigation into working conditions.2. Examination of chest with direct or specific roentgenography, cytological examination on sputum, bronchoscopy, or dermato-pathological examination, when found necessary by medical doctors.
(20) Work to manufacture or handle arsenic trioxide (inclusive of chemicals and other substances which contain arsenic trioxide of more than 1% by weight.)	1. Investigation into working conditions. 2. Examination of chest with direct or specific roentgenography, measurement of hair or urinary arsenic levels, hepatic functional test, blood testing of erythrocytic system, cytological examination on sputum, bronchoscopy, or dermato-pathological examination, when found necessary by medical doctors.
(21) Work to manufacture or handle 3,3' -dichloro-4,4' - diaminodiphenyl methane (inclusive of chemicals and other substances which contain 3,3' -dichloro-4,4' - diaminodiphenyl methane of more than 1% by weight.)	1. Investigation into working conditions.2. Examination of chest with direct or specific roentgenography, cytological examination on sputum, bronchoscopy, or renal functional examination, when found necessary by medical doctors.
(22) Work to manufacture or handle methyl bromide (inclusive of chemicals and substances which contain methyl bromide of more than 1% by weight.)	1. Investigation into working conditions.2. Examination of motor function, visual acuity, visual field, or EEG, when found necessary by medical doctors.
(23) Work to manufacture or handle mercury or its inorganic compounds (inclusive of chemicals and other substances which contain mercury or its inorganic compounds of more than 1% by weight.)	1. Investigation into working conditions.2. Neurological examination.3. Measurement of urinary mercury levels and urinary sediments tests.
(24) Work to manufacture of handle trilenediisocyanate (inclusive of chemicals and other substances which contain trilene- diisocyanate of more than 1% by weight.)	1. Investigation into working conditions.2. Physical examination of chest, examination of chest with direct roentgenography, or examination of occlusive changes of respiratory functions when existing subjective or objective symptoms of lungsare noted.3. Hepatic function tests, renal function tests, or examination of allergic reaction when found necessary by medical doctors.
(25) Work to manufacture or handle nickel carbonyl (inclusive of chemicals and other substances which contain nickel carbonyl of more than 1% by weight.)	1. Investigation into working conditions.2. Examination of pulmonary ventilation functions.3. Physical examination of chest.4. Measurement of urinary or blood nickel levels when found necessary by medical doctors.
(26) Work to manufacture or handle nitroglycol (inclusive of chemicals and other substances which contain nitroglycol of more than 1% by weight.)	1. Investigation into working conditions.2. Measurement of urinary or blood nitroglycol levels.3. Blood testing on the two items out of the measurement of hematocrit values, blood count of red blood cells and measurement of hemoglobin, when abnormalities were found as a result of the testing of blood total specific gravity.4. Testing for the presence of urinary urobilinogen and of protein.5. Examination with ECG.6. Examination of automatic nervous systems (exclusive of that conducted with drugs), hepatic functional examination, and circulatory functional examinationwhen found necessary by medical doctors.
(27) Work to manufacture or handle P-nitrochlorobenzene (inclusive of chemicals and other substances which contain P-nitrochlorobenzene of more than 5% by weight.)	1. Investigation into working conditions.2. Blood testing of erythrocytic system covering blood total specific gravity, blood count of red blood cells, reticulocytes count, methemoglobin levels and the presence of Heinz body.3. Testing for urinary occult blood.4. Hepatic function examination.5. Neurological examination.6. Measurement of urinary aniline or P-aminophenol or measurement of metabolites in blood such as nitrosoamine and hydroxyamine, aminophenol, quinone-imine, etc., when found necessary by medical doctors.
(28) Work to manufacture or handle hydrogen fluoride (inclusive of chemicals and other substances which contain hydrogen fluoride of more than 5% by weight.)	1. Investigation into working conditions.2. Chest physical examination or examination of chest with direct roentgenography.3. Blood testing of erythrocytic system covering total blood specific gravity, blood count of red blood cells, etc.4. Measurement of bleeding time, examination of long bones with roentgenography, hepatic function examination, measurement of urinary fluorine, or measurement of blood acidic phosphatase or calcium when found necessary by medical doctors.
(29) Work to manufacture or handle β-propiolactone (inclusive of chemicals and other substances which contain betapropiolactone of more than 1% by weight)	1. Investigation into working conditions.2. Examination of chest with specific roentgenography, cytological examination on sputum, bronchoscopy, and dermato-pathological examination when found necessary by doctors.
(30) Work to manufacture or handle benzene, etc.	1. Investigation into working conditions.2. Scanning in terms of blood covering blood pictures and others.3. Neurological examination.
(31) Work to manufacture or handle pentachlorophenol (otherwise called PCP) or its sodium salts (inclusive of chemicals and other substances which contain pentachlorophenol of more than 1% by weight)	1. Investigation into working conditions.2. Chest physical examination and examination of chest with direct roentgenography when objective or subjective symptoms are noted in respiratory organs.3. Hepatic function examination.4. Blood count of white blood cells.5. Measurement of urinary pentachlorophenol, when found necessary by medical doctors.
(32) Working to manufacture or handle manganese or its compounds (inclusive of chemicals and other substances which contain manganese or its compounds of more than 1% by weight)	1. Investigation into working conditions.2. Chest physical examination and examination of chest with direct roentgenography when objective or subjective symptoms are noted in respiratory organs.3. Neurological examination for Parkinson's-syndrome-like symptoms.4. Measurement of urinary or blood manganese levels, when found necessary by medical doctors.
(33) Work to manufacture or handle methyl iodide (inclusive of chemicals and other substances which contain methyl iodide of more than 1% by weight)	1. Investigation into working conditions.2. Ophthalmologic examination, motor neuron function examination, or neurological examination when found necessary by medical doctors.
(34) Work to manufacture or handle hydrogen sulfide (inclusive of chemicals and other substances which contain hydrogen sulfide of more than 1% by weight)	1. Investigation into working conditions.2. Chest physical examination or examination of chest with direct roentgenography.
(35) Work to manufacture or handle dimethyl sulfide (inclusive of chemicals and other substances which contain dimethyl sulfide of more than 1% by weight)	1. Investigation into working conditions.2. Chest physical examination or examination of chest with direct roentgenography.3. Hepatic function tests, renal function tests or examination of pulmonary ventilation functions, when found necessary by medical doctors.
(36) Work to manufacture or handle the chemicals given below, for use in experimentation and research. 1) 4-aminodiphenyl and its salts. 2) 4-nitrodiphenyl and its salts. 3) Chemicals and other substances which contain substances listed in 1) and 2) of more than 1% by weight.	1. Investigation into working conditions.2. Cystoscopy or pyelography, when found necessary by medical doctors.

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